Sepsis and Acute Kidney Injury (AKI): Which is More Important, Sepsis Biomarkers or AKI Biomarkers?
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References
1. Zarbock, A.; Nadim, M.K.; Pickkers, P.; Gomez, H.; Bell, S.; Joannidis, M.; Kashani, K.; Koyner, J.L.; Pannu, N.; Meersch, M.; et al. Sepsis-associated acute kidney injury: Consensus report of the 28th Acute Disease Quality Initiative workgroup. Nat. Rev. Nephrol. 2023, 19, 401–417.
2. Gist KM, Fuhrman D, Stanski N, Menon S, Soranno DE. Subphenotypes of acute kidney injury in children. Curr Opin Crit Care. 2022 Dec 1;28(6):590-598. doi: 10.1097/MCC.0000000000000986. Epub 2022 Sep 28. PMID: 36044290; PMCID: PMC9612688.
3. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. PMID: 26903338; PMCID: PMC4968574.
4. Samsu N, Marzuki MJ, Pratiwi IC et al. Predictors in-hospital mortality of septic vs non-septic acute kidney injury patients: an observational cohort study [version 2; peer review: awaiting peer review]. F1000Research 2022, 10:1184.
5. Ferreira, G.S.; Frota, M.L.; Gonzaga, M.J.D.; Vattimo, M.d.F.F.; Lima, C. The Role of Biomarkers in Diagnosis of Sepsis and Acute Kidney Injury. Biomedicines 2024, 12, 931. https://doi.org/10.3390/biomedicines12050931
6. Prescott, Hallie C. Antonelli, Massimo Alhazzani, Waleed et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026. Critical Care Medicine 54(4):p 725-812, April 2026. | DOI: 10.1097/CCM.0000000000007075
7. Gando, S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit. Care Med. 2010, 38, S35–S42
8. Hotabilardus, N., & Anggraeni, N. (2025). The Differentiating of Sepsis-Associated and Sepsis-Induced Acute Kidney Injury in Intensive Care Unit Patients. Indonesian Journal of Anesthesiology and Reanimation, 7(1), 53–65. https://doi.org/10.20473/ijar.V7I12025.53-65
9. Wahyudi A, Priyono D, Viotra D, et al. Diagnostic Value of Proenkephalin A 119–159 Serum in Early Detection of Sepsis-Associated Acute Kidney Injury. InaKidney. 2026;3(1):170-177. doi:10.32867/inakidney.v3i1.239
10. Khorashadi, M.; Beunders, R.; Pickkers, P.; Legrand, M. Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury. Nephron 2020, 144, 655–661.
2. Gist KM, Fuhrman D, Stanski N, Menon S, Soranno DE. Subphenotypes of acute kidney injury in children. Curr Opin Crit Care. 2022 Dec 1;28(6):590-598. doi: 10.1097/MCC.0000000000000986. Epub 2022 Sep 28. PMID: 36044290; PMCID: PMC9612688.
3. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. PMID: 26903338; PMCID: PMC4968574.
4. Samsu N, Marzuki MJ, Pratiwi IC et al. Predictors in-hospital mortality of septic vs non-septic acute kidney injury patients: an observational cohort study [version 2; peer review: awaiting peer review]. F1000Research 2022, 10:1184.
5. Ferreira, G.S.; Frota, M.L.; Gonzaga, M.J.D.; Vattimo, M.d.F.F.; Lima, C. The Role of Biomarkers in Diagnosis of Sepsis and Acute Kidney Injury. Biomedicines 2024, 12, 931. https://doi.org/10.3390/biomedicines12050931
6. Prescott, Hallie C. Antonelli, Massimo Alhazzani, Waleed et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026. Critical Care Medicine 54(4):p 725-812, April 2026. | DOI: 10.1097/CCM.0000000000007075
7. Gando, S. Microvascular thrombosis and multiple organ dysfunction syndrome. Crit. Care Med. 2010, 38, S35–S42
8. Hotabilardus, N., & Anggraeni, N. (2025). The Differentiating of Sepsis-Associated and Sepsis-Induced Acute Kidney Injury in Intensive Care Unit Patients. Indonesian Journal of Anesthesiology and Reanimation, 7(1), 53–65. https://doi.org/10.20473/ijar.V7I12025.53-65
9. Wahyudi A, Priyono D, Viotra D, et al. Diagnostic Value of Proenkephalin A 119–159 Serum in Early Detection of Sepsis-Associated Acute Kidney Injury. InaKidney. 2026;3(1):170-177. doi:10.32867/inakidney.v3i1.239
10. Khorashadi, M.; Beunders, R.; Pickkers, P.; Legrand, M. Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury. Nephron 2020, 144, 655–661.
Published
2026-04-24
How to Cite
1.
Samsu N. Sepsis and Acute Kidney Injury (AKI): Which is More Important, Sepsis Biomarkers or AKI Biomarkers?. inakidney [Internet]. 24Apr.2026 [cited 24Apr.2026];3(1):151-3. Available from: https://www.inakidneyhypertension.co.id/index.php/inakidney/article/view/248
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Editorial
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